[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester
CAS No.:1271523-27-3
Molecular Formula:C₂₈H₂₆Cl₃N₃O₄
Molecular Weight:574.891
Hs Code.:

Synonyms:[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

There total 10 articles about [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73852-18-3
(2,4,6-trichlorophenyl)boronic acid

: 376584-36-0
[5-chloro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 1271523-27-3
[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With potassium carbonate; silver carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 72h; Reflux;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1271523-27-3
[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / Reflux

2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.75 h / -78 °C / Inert atmosphere

3.3: -78 - 20 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

5.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

With potassium tert-butylate; hydrogen; potassium carbonate; N,N-dimethyl-aniline; silver carbonate; trichlorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; acetic acid; toluene;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1271523-27-3
[1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: bis(trichloromethyl) carbonate / tetrahydrofuran / 20 °C

3.1: acetic acid / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / Reflux

5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 0.75 h / -78 °C / Inert atmosphere

5.3: -78 - 20 °C / Inert atmosphere

6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane

7.1: potassium carbonate; silver carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 72 h / Reflux

With bis(trichloromethyl) carbonate; potassium tert-butylate; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-aniline; silver carbonate; trichlorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; toluene;