N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester

Base Information

• Chemical Name: N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester
• CAS No.: 126133-71-9
• Molecular Formula: C₄₆H₅₆N₄O₂₀
• Molecular Weight: 984.965
• Mol file: 126133-71-9.mol

Synonyms:N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester

Chemical Property of N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester

There total 4 articles about N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-Allyloxycarbonyl-L-threonin-tert-butylester (126133-63-9) + 2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide (87376-57-6) → N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-β-D-galactopyranosyl)>-L-threonin-tert-butylester + N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester (126133-71-9)

Guidance literature:

With 4 A molecular sieve; silver perchlorate; In dichloromethane; toluene; at -30 ℃; for 24h;

Reference yield:

N-(allyloxycarbonyl)-L-threonine (126133-58-2) → N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester (126133-71-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 40 h / Ambient temperature

2: konz. H₂SO₄ / CH₂Cl₂ / 116 h / Ambient temperature

3: N₂H₄*H₂O / ethanol / 1 h

4: 71 percent / molecular sieve (4 Angstroem), AgClO₄ / CH₂Cl₂; toluene / 24 h / -30 °C

With 4 A molecular sieve; sulfuric acid; silver perchlorate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; toluene;

Reference yield:

O-Acetoacetyl-N-allyloxycarbonyl-L-threonin (126133-59-3) → N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester (126133-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: konz. H₂SO₄ / CH₂Cl₂ / 116 h / Ambient temperature

2: N₂H₄*H₂O / ethanol / 1 h

3: 71 percent / molecular sieve (4 Angstroem), AgClO₄ / CH₂Cl₂; toluene / 24 h / -30 °C

With 4 A molecular sieve; sulfuric acid; silver perchlorate; hydrazine hydrate; In ethanol; dichloromethane; toluene;

upstream raw materials:

N-Allyloxycarbonyl-L-threonin-tert-butylester

2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide

N-(allyloxycarbonyl)-L-threonine

O-Acetoacetyl-N-allyloxycarbonyl-L-threonin

Downstream raw materials:

N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-(1<*>3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin

O-<(2,3,4,6-Tetra-O-acetyl-β-galactopyranosyl)-(1<*>3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester