(E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride

Base Information

• Chemical Name: (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride
• CAS No.: 1245710-97-7
• Molecular Formula: C₂₇H₂₅ClF₂N₈O₂*ClH
• Molecular Weight: 603.459
• Mol file: 1245710-97-7.mol

Synonyms:(E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride

Chemical Property of (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride

There total 2 articles about (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}-[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-carbamic acid tert-butyl ester (1263387-86-5) → (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride (1245710-97-7)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmc.2010.08.004

Reference yield:

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester (1245710-86-4) → (E)-4-{[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-amino}-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide hydrochloride (1245710-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper; copper(II) sulfate / N,N-dimethyl-formamide; water / 0.25 h / 125 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; copper; copper(II) sulfate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}-[1-(2-fluoroethyl)-1H-[1,2,3]triazol-4-ylmethyl]-carbamic acid tert-butyl ester

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}prop-2-ynyl carbamic acid tert-butyl ester