N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:165381-36-2
Molecular Formula:C₂₉H₂₇F₃N₆O₇
Molecular Weight:628.565
Hs Code.:

Synonyms:N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

There total 1 articles about N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 98-88-4
benzoyl chloride

: 165381-35-1
N-{3-[(2R,3R,4R,5R)-2-(6-Amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yloxy]-propyl}-2,2,2-trifluoro-acetamide

: 165381-36-2
N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With pyridine; at 20 ℃; for 8h;
DOI:10.1021/jm950937o

Reference yield: 75.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 165381-36-2
N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

: 165381-37-3
N-Benzoyl-N-(9-{(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With pyridine; at 20 ℃; for 16h;
DOI:10.1021/jm950937o

Reference yield:

: 165381-36-2
N-Benzoyl-N-(9-{(2R,3R,4R,5R)-4-hydroxy-5-hydroxymethyl-3-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

: Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-dibenzoylamino-purin-9-yl)-4-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pyridine / 16 h / 20 °C

2: 78 percent / (N,N-diisopropylamino)tetrazolide / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;
DOI:10.1021/jm950937o