methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate
CAS No.:959992-98-4
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

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Chemical Property of methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

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Technology Process of methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

There total 2 articles about methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 959992-96-2
2-prop-2-en-1-yl-1,8-naphthyridine

: 266306-18-7
(S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

: 959992-97-3
methyl N-(tert-butoxycarbonyl)-4-[3-(1,8-naphthyridin-2-yl)prop-1-en-1-yl]-L-phenylalaninate

: 959992-98-4
methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; at 150 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 61323-17-9
2-bromo-1,8-naphthyridine

: 959992-97-3
methyl N-(tert-butoxycarbonyl)-4-[3-(1,8-naphthyridin-2-yl)prop-1-en-1-yl]-L-phenylalaninate

: 959992-98-4
methyl N-(tert-butoxycarbonyl)-4-[1-methyl-2-(1,8-naphthyridin-2-yl)ethenyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 0.33 h / 150 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; cesium fluoride; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(o-tolyl)phosphine; In acetonitrile; 1: Suzuki Coupling;