3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

Base Information

Chemical Name:3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane
CAS No.:791595-66-9
Molecular Formula:C₃₀H₃₉F₃O₃Si
Molecular Weight:532.719
Hs Code.:

Synonyms:3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

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Chemical Property of 3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

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Technology Process of 3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

There total 6 articles about 3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 26357-07-3
3-(benzyloxy)-2-methoxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 791595-66-9
3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1021/jm049647a

Reference yield:

: 362-08-3,7683-30-9
2-methoxyestrone

: 791595-66-9
3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 19 h / 20 °C

2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049647a

Reference yield:

: 362-07-2
2-Methoxyestradiol

: 791595-66-9
3-benzyloxy-2-methoxy-17α-trifluoromethyl-1,3,5(10)-estratriene-17β-trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / aluminum isopropoxide / toluene; cyclohexane / 20 h / 145 - 150 °C

2: 88 percent / K₂CO₃ / dimethylformamide / 19 h / 20 °C

3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

With tetrabutyl ammonium fluoride; aluminum isopropoxide; potassium carbonate; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; toluene; 1: Oppenauer oxidation;
DOI:10.1021/jm049647a