(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Base Information

Chemical Name:(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine
CAS No.:639074-56-9
Molecular Formula:C₂₁H₂₀F₂N₂O
Molecular Weight:354.399
Hs Code.:

Synonyms:(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Suppliers and Price of (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

There total 9 articles about (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-1-Cyclopropyl-2-[(S)-4-(2,5-difluoro-phenyl)-2-phenyl-2,5-dihydro-pyrrol-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

: 639074-56-9
(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2006.01.030

Reference yield:

: 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-3,4-dihydro-2H-pyrrole

: 639074-56-9
(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Pt/C

2: HF*Et₃N

3: 85 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 - 0 °C

4: NaHMDS / tetrahydrofuran / -78 - 0 °C

5: Pd(PPh₃)4; Na₂CO₃ / dioxane / Heating

6: 100 percent / TFA / CH₂Cl₂

7: PyBOP; Et₃N / dimethylformamide / 23 °C

8: TFA / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hexamethyldisilazane; sodium carbonate; dimethyl sulfoxide; triethylamine hydrofluoride; triethylamine; trifluoroacetic acid; platinum on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4: Swern oxidation / 6: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.01.030

Reference yield:

: 635724-46-8
tert-butyl (2S)-4-oxo-2-phenylpyrrolidine-1-carboxylate

: 639074-56-9
(1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: NaHMDS / tetrahydrofuran / -78 - 0 °C

2: Pd(PPh₃)4; Na₂CO₃ / dioxane / Heating

3: 100 percent / TFA / CH₂Cl₂

4: PyBOP; Et₃N / dimethylformamide / 23 °C

5: TFA / CH₂Cl₂

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hexamethyldisilazane; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.01.030