5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

Base Information

Chemical Name:5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide
CAS No.:1355063-66-9
Molecular Formula:C₁₆H₁₃Cl₂FN₂O₄S
Molecular Weight:419.261
Hs Code.:

Synonyms:5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

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Chemical Property of 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

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Technology Process of 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

There total 6 articles about 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: 1355071-18-9
5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoic acid

: 1355063-66-9
5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; at 70 - 75 ℃; for 16h;

Reference yield:

: 96424-68-9
2-bromo-3-chloropyridine

: 1355063-66-9
5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / tricyclohexylphosphine; palladium diacetate / toluene; water / 6 h / 100 °C / Inert atmosphere

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C / Inert atmosphere

3: Oxone / water; acetone / 1 h / 0 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 50 °C

With Oxone; potassium phosphate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; palladium diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine; tricyclohexylphosphine; In n-heptane; water; dimethyl sulfoxide; acetone; toluene; acetonitrile;

Reference yield:

: 1355066-87-3
3-chloro-2-cyclopropylpyridine

: 1355063-66-9
5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / 20 °C / Inert atmosphere

2: Oxone / water; acetone / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 50 °C

With Oxone; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In n-heptane; water; dimethyl sulfoxide; acetone; acetonitrile;