1355066-87-3

Basic information

• Product Name: 3-chloro-2-cyclopropylpyridine
• Synonyms: 3-chloro-2-cyclopropylpyridine
• CAS NO: 1355066-87-3
• Molecular Formula: C₈H₈ClN
• Molecular Weight: 153.60882
• Mol File: 1355066-87-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-chloro-2-cyclopropylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-cyclopropylpyridine(1355066-87-3)
• EPA Substance Registry System: 3-chloro-2-cyclopropylpyridine(1355066-87-3)

Safety Data

• Hazardous Substances Data: 1355066-87-3(Hazardous Substances Data)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 23719-80-4 cyclopropylmagnesium bromide 
• 96424-68-9 2-bromo-3-chloropyridine 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 1355067-20-7 3-chloro-2-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1355063-66-9 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluoro-N-(methanesulfonyl)benzamide 
• 1355064-58-2 5-chloro-4-((5-chloro-6-cyclopropylpyridin-3-yl)methyl)-2-fluoro-N-(methylsulfonyl)benzamide 
• 1355067-22-9 4-methylphenyl 5-chloro-4-[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]-2-fluorobenzoate 
• 1355657-18-9 4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)benzamide 
• 1355657-14-5 4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)benzonitrile 
• 1355657-13-4 3-bromo-4-(5-chloro-6-cyclopropylpyridin-3-yloxy)benzonitrile 
• 1355656-38-0 4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide 

Relevant articles and documents

Chemoselective sp 2-sp3 cross-couplings: Iron-catalyzed alkyl transfer to dihaloaromatics

The chemoselective functionalization of a range of dihaloaromatics with methyl, cyclopropyl, and higher alkyl Grignard reagents via iron-catalyzed cross-coupling is described. The site selectivity of C-X (X = halogen) activation is determined by factors such as the position of the halogen on the ring, the solvent, and the nucleophile. A one-pot protocol for the chemoselective synthesis of mixed dialkyl heterocycles is achieved solely employing iron catalysis.

CHEMICAL COMPOUNDS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS

The invention relates to acyl sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new acyl sulfona