2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

Base Information

Chemical Name:2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol
CAS No.:475161-26-3
Molecular Formula:C₂₇H₃₁BrO₄
Molecular Weight:499.445
Hs Code.:

Synonyms:2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

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Chemical Property of 2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

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Technology Process of 2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

There total 6 articles about 2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 56517-32-9
2-bromo-4-methoxy-5-(1-methylethoxy)benzaldehyde

: 475161-25-2
1-bromo-2-(4-isopropoxybenzyl)benzene

: 475161-26-3
2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

Guidance literature:: 1-bromo-2-(4-isopropoxybenzyl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃; for 1h;

2-bromo-4-methoxy-5-(1-methylethoxy)benzaldehyde; In tetrahydrofuran; hexane; at -90 - 20 ℃; for 2h;
DOI:10.3390/70100018

Reference yield:

: 68355-78-2
1-bromo-2-(4-methoxybenzyl)benzene

: 475161-26-3
2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / boron tribromide / CH₂Cl₂ / -80 - 20 °C

2.1: 70 percent / potassium carbonate / acetonitrile / 96 h / 60 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -80 °C

3.2: 72 percent / hexane; tetrahydrofuran / 2 h / -90 - 20 °C

With n-butyllithium; boron tribromide; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.3390/70100018

Reference yield:

: 208035-01-2
4-(2-bromobenzyl)phenol

: 475161-26-3
2-bromo-5-isopropoxy-4-methoxyphenyl-[2-(4-isopropoxybenzyl)]-phenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / potassium carbonate / acetonitrile / 96 h / 60 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -80 °C

2.2: 72 percent / hexane; tetrahydrofuran / 2 h / -90 - 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.3390/70100018