ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate
CAS No.:913651-10-2
Molecular Formula:C₁₇H₂₀ClNO₃S
Molecular Weight:353.87
Hs Code.:

Synonyms:ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

Chemical Property:

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Technology Process of ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

There total 8 articles about ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913650-39-2
ethyl 2-[(5-chloro-2-hydroxyphenyl)methyl]-1,3-thiazole-4-carboxylate

: 513-38-2
Isobutyl iodide

: 913651-10-2
ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 6h;

Reference yield:

: 913650-10-9
2-(5-chloro-2-[(phenylmethyl)oxy]phenyl)ethanethioamide

: 913651-10-2
ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

1.2: 0.02 h

1.3: 1.5 h / 0 - 20 °C

2.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 100 °C

3.1: sulfuric acid / 2 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

With sulfuric acid; potassium carbonate; potassium hydrogencarbonate; sodium thiomethoxide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 149428-98-8
(5-chloro-2-((phenylmethyl)oxy)phenyl)acetic acid

: 913651-10-2
ethyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

2.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

3.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

3.2: 0.02 h

3.3: 1.5 h / 0 - 20 °C

4.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 100 °C

5.1: sulfuric acid / 2 h / Heating / reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

With Lawessons reagent; 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; sulfuric acid; potassium carbonate; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium thiomethoxide; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;