2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel
CAS No.:247141-82-8
Molecular Formula:C₅₈H₇₅NO₁₅Si₂
Molecular Weight:1082.4
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

There total 2 articles about 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 247141-81-7
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel

: 247141-82-8
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

: 247141-83-9
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-11,12-epoxy-A-norpaclitaxel

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/S0040-4020(99)00500-1

Reference yield:

: 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-A-norpaclitaxel

: 247141-82-8
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂; methanol

1.2: 91 percent / Me₃S

2.1: 69 percent / MCPBA; sodium bicarbonate / CH₂Cl₂ / 18 h / 20 °C

With sodium hydrogencarbonate; ozone; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; 1.1: Oxidation / 1.2: Reduction / 2.1: Oxidation;
DOI:10.1016/S0040-4020(99)00500-1