2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel

Base Information

• Chemical Name: 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel
• CAS No.: 247141-81-7
• Molecular Formula: C₅₈H₇₅NO₁₄Si₂
• Molecular Weight: 1066.4
• Mol file: 247141-81-7.mol

Synonyms:2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel

There total 1 articles about 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-A-norpaclitaxel → 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel (247141-81-7)

Guidance literature:

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-A-norpaclitaxel; With ozone; In methanol; dichloromethane;

With trimethylsulfonium;

DOI:10.1016/S0040-4020(99)00500-1

Reference yield: 69.0%

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel (247141-81-7) → 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel (247141-82-8) + 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-11,12-epoxy-A-norpaclitaxel (247141-83-9)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(99)00500-1

Reference yield:

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-A-norpaclitaxel (247141-81-7) → 1-deisopropenyl-1-acetoxy-A-norpaclitaxel

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / MCPBA; sodium bicarbonate / CH₂Cl₂ / 18 h / 20 °C

2: 79 percent / HCl/MeOH / 2 h / 20 °C

With hydrogenchloride; methanol; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: Oxidation / 2: Hydrolysis;

DOI:10.1016/S0040-4020(99)00500-1

Downstream raw materials:

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetoxy-A-norpaclitaxel

2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-1-deisopropenyl-1-acetyl-11,12-epoxy-A-norpaclitaxel