3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Base Information

Chemical Name:3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide
CAS No.:1610670-16-0
Molecular Formula:C₂₅H₂₅N₇O
Molecular Weight:439.52
Hs Code.:

Synonyms:3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

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Chemical Property of 3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

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Technology Process of 3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

There total 6 articles about 3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63744-59-2
t-butyl alamine

: 1610668-64-8
3-(4-aminophenyl)-N-(4-cyanophenyl)-N-methylimidazo[1.2-a]pyrazine-6-carboxamide

: 1610670-16-0
3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: t-butyl alamine; 3-(4-aminophenyl)-N-(4-cyanophenyl)-N-methylimidazo[1.2-a]pyrazine-6-carboxamide; With acetic acid; In ethanol; at 80 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In ethanol; at 0 ℃;

Reference yield:

: 1610667-21-4
3-bromo-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

: 1610670-16-0
3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dipotassium hydrogenphosphate / tetrahydrofuran; water / 0.75 h / 150 °C / Microwave irradiation

2.1: acetic acid / ethanol / 4 h / 80 °C

2.2: 0 °C

With dipotassium hydrogenphosphate; acetic acid; In tetrahydrofuran; ethanol; water; 1.1: |Suzuki Coupling;

Reference yield:

: 54013-06-8
ethyl 5-aminopyrazine-2-carboxylate

: 1610670-16-0
3-{4-[(2-amino-2-methylpropyl)amino]phenyl}-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; ethanol / 16 h / 90 °C

2.1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 1.5 h / 60 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 55 °C

4.2: 1 h / 20 °C

5.1: dipotassium hydrogenphosphate / tetrahydrofuran; water / 0.75 h / 150 °C / Microwave irradiation

6.1: acetic acid / ethanol / 4 h / 80 °C

6.2: 0 °C

With dipotassium hydrogenphosphate; N-Bromosuccinimide; oxalyl dichloride; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 5.1: |Suzuki Coupling;