Technology Process of Acetic acid (3S,4S,5S)-3,4-bis-benzyloxy-6,6,6-trifluoro-5-trifluoromethanesulfonyloxy-hexyl ester
There total 9 articles about Acetic acid (3S,4S,5S)-3,4-bis-benzyloxy-6,6,6-trifluoro-5-trifluoromethanesulfonyloxy-hexyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 0 ℃;
for 1.5h;
DOI:10.1021/jm960177x
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 1 h
2: 82 percent / 2 M aq. HCl, aq. AcOH / 0.5 h / 80 °C
3: 64 percent / BF3*Et2O / 1,2-dichloro-ethane / 3.5 h / 60 °C
4: 97 percent / pyridine
5: 99 percent / CaCO3, Hg(ClO4)2*3H2O / tetrahydrofuran; H2O / 1 h / Ambient temperature
6: 1.) Bu4NF*3H2O, 2.) 80percent aq. AcOH / 1.) THF, RT, 1.5 h, 2.) 50 deg C, 1.5 h
7: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C
With
pyridine; hydrogenchloride; mercury(II) perchlorate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; calcium carbonate;
In
tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jm960177x
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 1 h
2: 82 percent / 2 M aq. HCl, aq. AcOH / 0.5 h / 80 °C
3: 64 percent / BF3*Et2O / 1,2-dichloro-ethane / 3.5 h / 60 °C
4: 97 percent / pyridine
5: 99 percent / CaCO3, Hg(ClO4)2*3H2O / tetrahydrofuran; H2O / 1 h / Ambient temperature
6: 1.) Bu4NF*3H2O, 2.) 80percent aq. AcOH / 1.) THF, RT, 1.5 h, 2.) 50 deg C, 1.5 h
7: 93 percent / pyridine / CH2Cl2 / 1.5 h / 0 °C
With
pyridine; hydrogenchloride; mercury(II) perchlorate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; calcium carbonate;
In
tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/jm960177x
