4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine

Base Information

• Chemical Name: 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine
• CAS No.: 81243-95-0
• Molecular Formula: C₄₁H₅₅N₃O₇Si₂
• Molecular Weight: 758.075

Synonyms:4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine

Chemical Property of 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine

Chemical Property:

Purity/Quality:

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Technology Process of 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine

There total 3 articles about 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3',5'-O-[(1,1,3,3-tetraisopropyl)-1,3-disiloxanediyl]cytidine (69304-42-3) + mono-4-methoxytrityl chloride (14470-28-1) → 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine (81243-95-0)

Guidance literature:

With triethylamine; dmap; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1246/cl.1982.15

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine (81243-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / pyridine

2: 92 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; triethylamine; dmap; In dichloromethane;

DOI:10.1246/cl.1982.15

Reference yield:

CYTIDINE (65-46-3) → 4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-ribofuranosyl>cytosine (81243-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / pyridine

2: 92 percent / triethylamine / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; triethylamine; dmap; In dichloromethane;

DOI:10.1246/cl.1982.15

upstream raw materials:

3',5'-O-[(1,1,3,3-tetraisopropyl)-1,3-disiloxanediyl]cytidine

mono-4-methoxytrityl chloride

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

CYTIDINE

Downstream raw materials:

4-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-1-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

4-N-monomethoxytrityl-1-<3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-erythro-pentofuranos-2'-ulosyl>cytosine

4-N-monomethoxytrityl-1-<2'-C-cyano-2'-deoxy-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)-β-D-arabinofuranosyl>cytosine

1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-1H-pyrimidin-2-one

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