Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester
CAS No.:124409-74-1
Molecular Formula:C₂₆H₄₂O₄SSi
Molecular Weight:478.769
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

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Chemical Property of Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

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Technology Process of Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

There total 3 articles about Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 124409-62-7
Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-4-hydroxy-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

: 124409-74-1
Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/jm980031t

Reference yield:

: 93489-59-9
[1R-(3aβ(S*),7β,7aα)]-β,3a-dimethyl-4-hydroxy-(3a,4,5,6,7,7a)hexahydro-1H-indene-1-ethanol

: 124409-74-1
Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 0 °C

2: 86 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; dmap; In dichloromethane;
DOI:10.1021/jm980031t

Reference yield:

: 93489-58-8
(3aR,4S,7aS)-(Z)-1-ethylidene-7a-methyloctahydro-1H-4-indenol

: 124409-74-1
Toluene-4-sulfonic acid (S)-2-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) dimethylaluminum chloride / 1.) CH₂Cl₂, hexane, -78 deg C, 30 min, 2.) CH₂Cl₂, hexane, -40 deg C, 16 h

2: 93 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / 0 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; dmap; dimethylaluminum chloride; In dichloromethane;
DOI:10.1021/jm980031t