trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Base Information

Chemical Name:trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile
CAS No.:123596-27-0
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

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Chemical Property of trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

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Technology Process of trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

There total 2 articles about trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123596-26-9
trans-3,4-dihydro-3-hydroxy-4-(2-imino-1-pyrrolidinyl)-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

: 98-88-4
benzoyl chloride

: 123596-27-0
trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Guidance literature:: With triethylamine; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00164a005

Reference yield:

: 123595-70-0
(3RS,4SR)-4-amino-3-hydroxy-2,2-dimethylchroman-6-carbonitrile

: 123596-27-0
trans-4-<2-(benzoylimino)-1-pyrrolidinyl>-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, 2.) NaOH / 1.) 130 deg C, 3 h, 2.) water

2: 88 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

With sodium hydroxide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00164a005