(3,6-dibromopyridazin-4-yl)(phenyl)methanone

Base Information

• Chemical Name: (3,6-dibromopyridazin-4-yl)(phenyl)methanone
• CAS No.: 1424016-57-8
• Molecular Formula: C₁₁H₆Br₂N₂O
• Molecular Weight: 341.989
• Mol file: 1424016-57-8.mol

Synonyms:(3,6-dibromopyridazin-4-yl)(phenyl)methanone

Chemical Property of (3,6-dibromopyridazin-4-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,6-dibromopyridazin-4-yl)(phenyl)methanone

There total 1 articles about (3,6-dibromopyridazin-4-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,6-dibromopyridazine (17973-86-3) + benzoyl chloride (98-88-4) → (3,6-dibromopyridazin-4-yl)(phenyl)methanone (1424016-57-8)

Guidance literature:

3,6-dibromopyridazine; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

benzoyl chloride; With CCl₂CuLi₂N; In tetrahydrofuran; at -40 - 25 ℃; for 5h;

DOI:10.1021/ol400248e

Reference yield: 80.0%

n-octyne (629-05-0) + (3,6-dibromopyridazin-4-yl)(phenyl)methanone (1424016-57-8) → (3-bromo-6-(oct-1-yn-1-yl)pyridazin-4-yl)phenylmethanone (1424017-24-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; triethylamine; In tetrahydrofuran; at 50 ℃; for 3h; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol400248e

Reference yield: 75.0%

(3,6-dibromopyridazin-4-yl)(phenyl)methanone (1424016-57-8) → 5-bromo-3-phenyl-1H-pyrazolo[3,4-c]pyridazine (1424017-38-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.5h; regioselective reaction; Reflux;

DOI:10.1021/ol400248e

upstream raw materials:

3,6-dibromopyridazine

benzoyl chloride

Downstream raw materials:

(3,6-dibromo-5-iodopyridazin-4-yl)(phenyl)methanone

5-bromo-3-phenyl-1H-pyrazolo[3,4-c]pyridazine

(5-benzoyl-3,6-dibromopyridazin-4-yl)(furan-2-yl)methanone

(3,6-dibromo-5-(cyclohex-2-en-1-yl)pyridazin-4-yl)(phenyl)methanone

Refernces