methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

Base Information

Chemical Name:methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate
CAS No.:1276687-68-3
Molecular Formula:C₂₉H₃₀F₃N₃O₄
Molecular Weight:541.57
Hs Code.:

Synonyms:methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

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Chemical Property of methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

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Technology Process of methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

There total 7 articles about methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1276687-64-9
methyl (+/-)-4-(5-hydroxy-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 5407-04-5
3-(dimethylamino)propyl chloride hydrochloride

: 1276687-68-3
methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-56-9
methyl (+/-)-4-nitro-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-68-3
methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: iron; acetic acid / 0.75 h / 65 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

3: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; pyridinium p-toluenesulfonate; iron; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2: Buchwald-Hartwig reaction;
DOI:10.1021/jm1011726

Reference yield:

: 1276687-57-0
methyl (+/-)-4-amino-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

: 1276687-68-3
methyl (+/-)-4-(5-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 60 °C

2: hydrogen; pyridinium p-toluenesulfonate / ethyl acetate / 20 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; pyridinium p-toluenesulfonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Buchwald-Hartwig reaction;
DOI:10.1021/jm1011726