1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

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Chemical Name:1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole
CAS No.:209960-59-8
Molecular Formula:C₂₅H₁₅F₅N₄O₃S
Molecular Weight:546.477
Hs Code.:

Synonyms:1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

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Chemical Property of 1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

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Technology Process of 1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

There total 5 articles about 1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 209960-90-7
(2'-methylsulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine hydrochloride

: 209960-59-8
1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 209960-59-8
1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

2: (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0497949

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 209960-59-8
1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / SnCl₂*2H₂O / ethyl acetate / 1.5 h / Heating

2.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

2.2: stannous chloride; aq. HCl / 12 h / 0 °C

2.3: 7.0 g / acetic acid / 12 h / Heating

3.1: 64 percent / RuCl₃; aq. NaIO₄ / acetonitrile; CCl₄ / 12 h / 20 °C

4.1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h / Heating

5.1: (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; dmap; ruthenium trichloride; sodium periodate; oxalyl dichloride; N,N-dimethyl-formamide; tin(ll) chloride; sodium nitrite; In tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm0497949