methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate
CAS No.:1383421-98-4
Molecular Formula:C₂₄H₂₀O₅
Molecular Weight:388.42
Hs Code.:

Synonyms:methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

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Chemical Property of methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

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Technology Process of methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

There total 4 articles about methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1383421-97-3
methyl 4-((2,5-dimethoxy-4'-((tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

: 1383421-98-4
methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; at 20 ℃;
DOI:10.1039/c2jm31367g

Reference yield:

: 1383421-96-2
2-((4'-bromo-2',5'-dimethoxy-[1,1'-biphenyl]-4-yl)oxy)tetrahydro-2H-pyran

: 1383421-98-4
methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; triethylamine; triphenylphosphine / tetrahydrofuran / 0.08 h / Inert atmosphere

1.2: 70 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / methanol; dichloromethane / 20 °C

With copper(l) iodide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1039/c2jm31367g

Reference yield:

: 36603-49-3
4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

: 1383421-98-4
methyl 4-((4'-hydroxy-2,5-dimethoxy-[1,1'-biphenyl]-4-yl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate / ethanol; toluene / 0.17 h / 20 °C / Inert atmosphere

2.2: 6 h / 90 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; triphenylphosphine / tetrahydrofuran / 0.08 h / Inert atmosphere

3.2: 70 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol; dichloromethane / 20 °C

With copper(l) iodide; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; toluene; 2.1: Suzuki coupling / 2.2: Suzuki coupling / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1039/c2jm31367g