(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Base Information

Chemical Name:(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct
CAS No.:137649-17-3
Molecular Formula:C₃₉H₄₉N₃O₈
Molecular Weight:687.833
Hs Code.:

Synonyms:(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Suppliers and Price of (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

There total 2 articles about (25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 137649-16-2
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-17-3
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; for 1h; Ambient temperature;
DOI:10.1021/jo00027a010

Reference yield:

: 137649-15-1
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-17-3
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridinium p-toluenesulfonate / ethanol / 1 h / Heating

2: 99 percent / Et₃N, pyridine-SO₃ complex / dimethylsulfoxide; CH₂Cl₂ / 1 h / Ambient temperature

With sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; triethylamine; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00027a010

Reference yield:

: 137649-17-3
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-al 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-20-8,137764-46-6,143678-91-5
(23R,25R)-1α,3β,25-trihydroxy-5,7-cholestadiene 26,23-lactone 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: Multi-step reaction with 4 steps

1: KOH, I₂ / 0.5 h / 0 °C

2: 5percent aq.-methanolic KOH / 0.5 h / Ambient temperature

3: 80 percent / pyridine / CH₂Cl₂ / 1 h / -78 °C

4: 88 percent / tributyltin hydride, AIBN / toluene / 0.17 h / Heating

With pyridine; potassium hydroxide; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; In dichloromethane; toluene;
DOI:10.1021/jo00027a010