(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Base Information

Chemical Name:(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct
CAS No.:137649-15-1
Molecular Formula:C₄₂H₅₅N₃O₈
Molecular Weight:729.914
Hs Code.:

Synonyms:(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

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Chemical Property of (25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

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Technology Process of (25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

There total 1 articles about (25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 108-24-7
acetic anhydride

: 137649-14-0
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-15-1
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: With pyridine; dmap; for 3h; Ambient temperature;
DOI:10.1021/jo00027a010

Reference yield: 92.0%

: 137649-15-1
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-16-2
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; for 1h; Heating;
DOI:10.1021/jo00027a010

Reference yield:

: 137649-15-1
(25R)-5,7,22-cholestatriene-1α,3β,25,26-tetrol 1,3-diacetate 25,26-acetonide 4-phenyl-1,2,4-triazoline-3,5-dione adduct

: 137649-18-4
(25R)-1α,3β,25-trihydroxy-5,7,22-cholestatrien-26-oic acid 4-phenyl-1,2,4-triazoline-3,5-dione adduct

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / pyridinium p-toluenesulfonate / ethanol / 1 h / Heating

2: 99 percent / Et₃N, pyridine-SO₃ complex / dimethylsulfoxide; CH₂Cl₂ / 1 h / Ambient temperature

3: KOH, I₂ / 0.5 h / 0 °C

4: 5percent aq.-methanolic KOH / 0.5 h / Ambient temperature

With potassium hydroxide; iodine; sulfur trioxide pyridine complex; pyridinium p-toluenesulfonate; triethylamine; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00027a010