(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Chemical Name:(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate
CAS No.:1263941-17-8
Molecular Formula:C₂₈H₂₉F₃N₄O₂
Molecular Weight:510.559
Hs Code.:

Synonyms:(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Chemical Property of (R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Technology Process of (R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

There total 4 articles about (R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1150655-04-1
potassium [(dimethylamino)methyl](trifluoro)borate^(1-)

: 1263944-44-0
(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263941-17-8
(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: With caesium carbonate; XPhos; palladium diacetate; In 1,4-dioxane; water; at 160 ℃; for 4h; Inert atmosphere; Irradiation with microwave;

Reference yield:

: 1264296-05-0
ethyl 2-benzyl-5-(dimethylamino)-2-methyl-3-oxopent-4-enoate

: 1263941-17-8
(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / chloroform / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

3: Chiralcel OJ-H column / carbon dioxide; methanol / Resolution of racemate

4: caesium carbonate; XPhos / palladium diacetate / 1,4-dioxane; water / 4 h / 160 °C / Inert atmosphere; Irradiation with microwave

With hydrogenchloride; N-chloro-succinimide; caesium carbonate; XPhos; palladium diacetate; In 1,4-dioxane; methanol; ethanol; chloroform; carbon dioxide; water;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1263941-17-8
(R)-ethyl 2-(6-((dimethylamino)methyl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 90 °C

2: N-chloro-succinimide / chloroform / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

4: Chiralcel OJ-H column / carbon dioxide; methanol / Resolution of racemate

5: caesium carbonate; XPhos / palladium diacetate / 1,4-dioxane; water / 4 h / 160 °C / Inert atmosphere; Irradiation with microwave

With hydrogenchloride; N-chloro-succinimide; caesium carbonate; XPhos; palladium diacetate; In 1,4-dioxane; methanol; ethanol; chloroform; carbon dioxide; water; N,N-dimethyl-formamide;