(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Base Information

Chemical Name:(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate
CAS No.:1263944-44-0
Molecular Formula:C₂₅H₂₁ClF₃N₃O₂
Molecular Weight:487.909
Hs Code.:

Synonyms:(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

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Chemical Property of (R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Chemical Property:

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Technology Process of (R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

There total 4 articles about (R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264294-88-3
ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-40-6
(S)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-44-0
(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Chiralcel OJ-H column; In methanol; carbon dioxide; Resolution of racemate;

Reference yield:

: ethyl 2-benzyl-4-chloro-5-(dimethylamino)-2-methyl-3-oxopent-4-enoate

: 1263944-40-6
(S)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-44-0
(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

2: Chiralcel OJ-H column / carbon dioxide; methanol / Resolution of racemate

With hydrogenchloride; Chiralcel OJ-H column; In 1,4-dioxane; methanol; ethanol; carbon dioxide;

Reference yield:

: 107449-78-5
ethyl α-methyl-α-benzylacetoacetate

: 1263944-40-6
(S)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

: 1263944-44-0
(R)-ethyl 2-(6-chloro-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 90 °C

2: N-chloro-succinimide / chloroform / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; ethanol / 0.33 h / 160 °C / Irradiation with microwave

4: Chiralcel OJ-H column / carbon dioxide; methanol / Resolution of racemate

With hydrogenchloride; N-chloro-succinimide; Chiralcel OJ-H column; In 1,4-dioxane; methanol; ethanol; chloroform; carbon dioxide; N,N-dimethyl-formamide;