N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide

Base Information

• Chemical Name: N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide
• CAS No.: 349649-34-9
• Molecular Formula: C₂₀H₂₃N₅O₈S
• Molecular Weight: 493.497

Synonyms:N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide

Chemical Property of N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide

Chemical Property:

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Technology Process of N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide

There total 2 articles about N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

N-(6-aminopropyl)-2-nitrobenzenesulfonamide (240423-09-0) + N-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamic acid ethyl ester (349649-33-8) → N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide (349649-34-9)

Guidance literature:

In dichloromethane; for 48h;

DOI:10.1021/ja010220s

Reference yield:

5-amino-2-methoxy-N-methylbenzamide hydrochloride → N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide (349649-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 0.25 h

2: 44 percent / CH₂Cl₂ / 48 h

With triethylamine; In dichloromethane;

DOI:10.1021/ja010220s

Reference yield: 52.0%

2-(tert-butoxycarbonylamino)ethyl bromide (39684-80-5) + N-(4-methoxy-3-methylcarbamoyl-phenyl)-N'-[3-(2-nitro-benzenesulfonylamino)-propyl]-oxalamide (349649-34-9) → {2-[{3-[(4-methoxy-3-methylcarbamoyl-phenylaminooxalyl)-amino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (349649-35-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 20h;

DOI:10.1021/ja010220s

upstream raw materials:

N-(6-aminopropyl)-2-nitrobenzenesulfonamide

N-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamic acid ethyl ester

Downstream raw materials:

{2-[{3-[(4-methoxy-3-methylcarbamoyl-phenylaminooxalyl)-amino]-propyl}-(2-nitro-benzenesulfonyl)-amino]-ethyl}-carbamic acid tert-butyl ester

N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

N-(3-{1-[2-(2-cyano-ethylamino)-ethyl]-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

(S)-2-[(S)-2-(3-(2-tert-Butoxycarbonylamino-ethyl)-3-{3-[(4-methoxy-3-methylcarbamoyl-phenylaminooxalyl)-amino]-propyl}-ureido)-3-phenyl-propionylamino]-4-methyl-pentanoic acid methyl ester

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