2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

Base Information

Chemical Name:2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide
CAS No.:1319735-77-7
Molecular Formula:C₁₈H₁₈N₄O₃
Molecular Weight:338.366
Hs Code.:

Synonyms:2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

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Chemical Property of 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

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Technology Process of 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

There total 5 articles about 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1319735-76-6
ethyl 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetate

: 1319735-77-7
2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 8h;
DOI:10.1007/s00706-011-0525-3

Reference yield: 90.0%

: 64-17-5
ethanol

: 1319735-76-6
ethyl 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetate

: 1319735-77-7
2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

Guidance literature:: With hydrazine; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2011.11.007

Reference yield:

: 5060-53-7
8-hydroxy-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

: 1319735-77-7
2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 6 h / 20 °C

2: hydrazine hydrate / ethanol / 8 h / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;
DOI:10.1007/s00706-011-0525-3