1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

Base Information

Chemical Name:1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride
CAS No.:83552-42-5
Molecular Formula:C₈H₁₃NO₂S₂*ClH
Molecular Weight:255.79
Hs Code.:

Synonyms:1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

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Chemical Property of 1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

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Technology Process of 1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

There total 1 articles about 1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 83552-42-5
1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

2: HCl / acetic acid / 1 h / Heating

3: HCl / 1.) -30 deg C, 2 h, 2.) room temperature, 24 h

With hydrogenchloride; boron trifluoride diethyl etherate; In dichloromethane; acetic acid;
DOI:10.1021/jm00401a014

Reference yield: 92.0%

: 83552-42-5
1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

: 83623-61-4
(hydroxy(4-phenylbutyl)-phosphinyl)acetic acid

: 83623-48-7
(S)-7-{2-[Hydroxy-(4-phenyl-butyl)-phosphinoyl]-acetyl}-1,4-dithia-7-aza-spiro[4.4]nonane-8-carboxylic acid methyl ester

Guidance literature:: With triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00401a014

Reference yield:

: 83552-42-5
1,4-dithia-7-diazaspiro<4.4>nonane-8-carboxylic acid methyl ester monohydrochloride

: 83623-49-8
(S)-7-[[Hydroxy(4-phenylbutyl)phosphinyl)acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / carbodiimidazole, Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 84 percent / 1N NaOH / 0.5 h

With sodium hydroxide; triethylamine; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1021/jm00401a014