methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

Base Information

• Chemical Name: methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate
• CAS No.: 1114592-06-1
• Molecular Formula: C₁₆H₂₂ClN₃O₂
• Molecular Weight: 323.823

Synonyms:methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

Chemical Property of methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

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Technology Process of methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

There total 2 articles about methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

cyclohexyl-cyclopropylmethyl-amine; hydrochloride (99175-39-0) + 2,6-dichloropyrimidine-4-carboxylic acid methyl ester (6299-85-0) → methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate (1114592-06-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 48h;

Reference yield:

N-(cyclopropylmethyl)cyclohexanamine (99175-40-3) + 2,6-dichloropyrimidine-4-carboxylic acid methyl ester (6299-85-0) → methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate (1114592-06-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.bmcl.2010.01.102

Reference yield: 97.0%

methyl 2-chloro-6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate (1114592-06-1) → methyl 6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate (1114592-07-2)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In water; isopropyl alcohol; at 20 ℃; for 0.75h;

upstream raw materials:

cyclohexyl-cyclopropylmethyl-amine; hydrochloride

2,6-dichloropyrimidine-4-carboxylic acid methyl ester

N-(cyclopropylmethyl)cyclohexanamine

Downstream raw materials:

methyl 6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylate

6-[cyclohexyl(cyclopropylmethyl)amino]pyrimidine-4-carboxylic acid

6-[cyclohexyl(cyclopropylmethyl)amino]-N-(4-formylphenyl)pyrimidine-4-carboxamide

6-[cyclohexyl(cyclopropylmethyl)amino]-N-[4-(hydroxymethyl)phenyl]pyrimidine-4-carboxamide

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