pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Base Information

Chemical Name:pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester
CAS No.:1318787-27-7
Molecular Formula:C₂₅H₂₅FN₄O₅
Molecular Weight:480.496
Hs Code.:

Synonyms:pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Suppliers and Price of pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

There total 3 articles about pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 736131-48-9,752198-38-2
(S)-3-amino-3-(2-methylphenyl)propionic acid

: 1318790-03-2
1-(2-fluoro-phenyl)-5-(pyrrolidine-1-carbonyloxy)-1H-pyrazole-3-carboxylic acid

: 1318787-27-7
pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Guidance literature:: 1-(2-fluoro-phenyl)-5-(pyrrolidine-1-carbonyloxy)-1H-pyrazole-3-carboxylic acid; With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 0.0833333h;

(S)-3-amino-3-(2-methylphenyl)propionic acid; at 20 ℃;

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1318787-27-7
pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / water / 2.42 h

2.1: caesium carbonate / tetrahydrofuran / 4 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / 0.08 h / 20 °C

3.2: 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; sulfuric acid; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;

Reference yield:

: 1318789-59-1
1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylic acid

: 1318787-27-7
pyrrolidine-1-carboxylic acid 5-((S)-2-carboxy-1-o-tolyl-ethylcarbamoyl)-2-(2-fluoro-phenyl)-2H-pyrazol-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrahydrofuran / 4 h / 50 °C

2.1: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / 0.08 h / 20 °C

2.2: 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;