3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

Base Information

Chemical Name:3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate
CAS No.:1311371-85-3
Molecular Formula:C₂F₃O₂*C₃₂H₃₇Cl₂F₂N₄O₃S₂
Molecular Weight:811.722
Hs Code.:

3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

Synonyms:3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

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Chemical Property of 3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

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Technology Process of 3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

There total 14 articles about 3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239956-94-5
4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

: 3779-42-8
3-bromo-N,N,N-trimethyl-1-propanaminium bromide

: 76-05-1
trifluoroacetic acid

: 1311371-85-3
3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

Guidance literature:: 4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide; 3-bromo-N,N,N-trimethyl-1-propanaminium bromide; With potassium carbonate; In acetonitrile; at 20 ℃; for 12h;

trifluoroacetic acid;

Reference yield:

: 16817-43-9
5-Bromo-2-chloroanisole

: 1311371-85-3
3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / toluene; hexane / 0.33 h / 0 - 15 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: potassium trimethylsilonate / tert-butyl methyl ether; tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2.2: pH 1

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

4.1: tetrahydrofuran / 2 h / -78 - 20 °C

5.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

9.1: acetic acid / 4 h / Reflux

10.1: potassium carbonate / acetone / 3 h

11.1: potassium carbonate / acetonitrile / 12 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium azide; tetra-n-butylammonium tribromide; potassium trimethylsilonate; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-cyclohexyl-cyclohexanamine; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1311371-85-3
3-(4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorophenylsulfonamido)-N,N,N-trimethylpropan-1-aminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: sulfuric acid / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

7: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8: acetic acid / 4 h / Reflux

9: potassium carbonate / acetone / 3 h

10: potassium carbonate / acetonitrile / 12 h / 20 °C

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; sulfuric acid; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;