4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

Base Information

Chemical Name:4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide
CAS No.:1239956-94-5
Molecular Formula:C₂₆H₂₃Cl₂F₂N₃O₃S₂
Molecular Weight:598.522
Hs Code.:

Synonyms:4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

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Chemical Property of 4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

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Technology Process of 4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

There total 13 articles about 4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-46-2
5-(bromomethyl)-4-chloro-2-fluorobenzenesulfonamide

: 1239963-85-9
5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

: 1239956-94-5
4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

Guidance literature:: With potassium carbonate; In acetone; for 3h;

Reference yield:

: 1239963-78-0
2-(4-chloro-3-methoxyphenyl)-2-methylpropanoic acid

: 1239956-94-5
4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: tetrahydrofuran / 2 h / -78 - 20 °C

3: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

6: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7: acetic acid / 4 h / Reflux

8: potassium carbonate / acetone / 3 h

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239956-94-5
4-chloro-5-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-2-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / 4 h / Reflux

7: potassium carbonate / acetone / 3 h

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; potassium carbonate; acetic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;