(R)-2-benzyloxy-3,3,3-trifluoropropanol

Base Information

• Chemical Name: (R)-2-benzyloxy-3,3,3-trifluoropropanol
• CAS No.: 165801-06-9
• Molecular Formula: C₁₀H₁₁F₃O₂
• Molecular Weight: 220.191
• Mol file: 165801-06-9.mol

Synonyms:(R)-2-benzyloxy-3,3,3-trifluoropropanol

Chemical Property of (R)-2-benzyloxy-3,3,3-trifluoropropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-benzyloxy-3,3,3-trifluoropropanol

There total 2 articles about (R)-2-benzyloxy-3,3,3-trifluoropropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.7%

(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone (165801-12-7) → (R)-2-benzyloxy-3,3,3-trifluoropropanol (165801-06-9)

Guidance literature:

With lithium borohydride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/0957-4166(94)80046-4

Reference yield:

(R)-3-(2-benzyloxyacetyl)-4-isopropyl-2-oxazolidinone (154878-15-6) → (R)-2-benzyloxy-3,3,3-trifluoropropanol (165801-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, 2.) Et₃B / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, from -78 to -20 deg C, 130 min

2: 49.7 percent / LiBH₄ / diethyl ether / 1 h / 0 °C

With lithium borohydride; triethyl borane; lithium diisopropyl amide; In diethyl ether;

DOI:10.1016/0957-4166(94)80046-4

Reference yield:

(R)-2-benzyloxy-3,3,3-trifluoropropanol (165801-06-9) → (R)-2-Benzyloxy-3,3,3-trifluoro-propionic acid

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; at 0 - 20 ℃; for 26h;

DOI:10.1016/0957-4166(94)80046-4

upstream raw materials:

(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

(R)-3-(2-benzyloxyacetyl)-4-isopropyl-2-oxazolidinone

Downstream raw materials:

(2R)-methyl 2-(benzyloxy)-3,3,3-trifluoropropionate