(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

Base Information

• Chemical Name: (2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone
• CAS No.: 165801-12-7
• Molecular Formula: C₁₆H₁₈F₃NO₄
• Molecular Weight: 345.318
• Mol file: 165801-12-7.mol

Synonyms:(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

Chemical Property of (2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

There total 1 articles about (2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodotrifluoromethane (2314-97-8,263005-66-9) + (R)-3-(2-benzyloxyacetyl)-4-isopropyl-2-oxazolidinone (154878-15-6) → (2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone (165801-12-7) + (2'S,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone

Guidance literature:

With triethyl borane; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, from -78 to -20 deg C, 130 min;

DOI:10.1016/0957-4166(94)80046-4

Reference yield: 49.7%

(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone (165801-12-7) → (R)-2-benzyloxy-3,3,3-trifluoropropanol (165801-06-9)

Guidance literature:

With lithium borohydride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/0957-4166(94)80046-4

Reference yield:

(2'R,4R)-3-(2'-benzyloxy-3',3',3'-trifluoropropionyl)-4-isopropyl-2-oxazolidinone (165801-12-7) → (2R)-methyl 2-(benzyloxy)-3,3,3-trifluoropropionate (140404-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 49.7 percent / LiBH₄ / diethyl ether / 1 h / 0 °C

2: CrO₃, H₂SO₄ / H₂O / 26 h / 0 - 20 °C

3: diethyl ether / 0 °C

With chromium(VI) oxide; lithium borohydride; sulfuric acid; In diethyl ether; water;

DOI:10.1016/0957-4166(94)80046-4

upstream raw materials:

iodotrifluoromethane

(R)-3-(2-benzyloxyacetyl)-4-isopropyl-2-oxazolidinone

Downstream raw materials:

(R)-2-benzyloxy-3,3,3-trifluoropropanol

(2R)-methyl 2-(benzyloxy)-3,3,3-trifluoropropionate