2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

Base Information

• Chemical Name: 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one
• CAS No.: 871210-05-8
• Molecular Formula: C₂₅H₂₀F₁₃NO₃
• Molecular Weight: 629.418
• Mol file: 871210-05-8.mol

Synonyms:2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

Chemical Property of 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

There total 5 articles about 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

[(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester (114744-85-3) → 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one (871210-05-8)

Guidance literature:

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane; With tert.-butyl lithium; In diethyl ether; hexane; pentane; at -78 - -60 ℃; for 90h;

[(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester; In diethyl ether; hexane; pentane; at -78 - 20 ℃; for 2.25h; Product distribution / selectivity;

Reference yield: 15.0%

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane (2043-57-4,71215-70-8) + N-carbobenzoxy-L-phenylalanine methyl ester (35909-92-3) → 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one (871210-05-8) + 2(S)-(benzyloxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol (871210-10-5)

Guidance literature:

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane; With magnesium; In diethyl ether;

N-carbobenzoxy-L-phenylalanine methyl ester; In diethyl ether; for 4h;

DOI:10.1021/jo051696n

Reference yield:

N-carbobenzoxy-L-phenylalanine methyl ester (35909-92-3) → 2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one (871210-05-8)

Guidance literature:

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane; With tert.-butyl lithium; In diethyl ether; hexane; pentane; at -78 - -60 ℃; for 90h;

N-carbobenzoxy-L-phenylalanine methyl ester; In diethyl ether; hexane; pentane; at -78 - 20 ℃; for 2.25h; Product distribution / selectivity;

upstream raw materials:

1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

N-carbobenzoxy-L-phenylalanine methyl ester

[(S)-1-(methoxy-methyl-carbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

Downstream raw materials:

(4S,5R)-4-benzyl-5-(1'H,1'H,2'H,2'H-perfluorooctyl)-oxazolidin-2-one

(2S,3R)-2-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-ol