Z-Phe-ome

Base Information

• Chemical Name: Z-Phe-ome
• CAS No.: 35909-92-3
• Molecular Formula: C18H19 N O4
• Molecular Weight: 313.353
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60189481
• Nikkaji Number: J240.047B
• Wikidata: Q83061585
• Mol file: 35909-92-3.mol

Synonyms:N-benzyloxycarbonyl-L-phenylalanine methyl ester;N-benzyloxycarbonylphenylalanine methyl ester;Z-Phe-OMe

Chemical Property of Z-Phe-ome

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 478.5°Cat760mmHg
• Flash Point: 243.2°C
• PSA: 64.63000
• Density: 1.181g/cm³
• LogP: 3.08800
• Storage Temp.: -15°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 313.13140809
• Heavy Atom Count: 23
• Complexity: 373

Purity/Quality:

97% ^*data from raw suppliers

Z-L-phenylalanine methyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
• Isomeric SMILES: COC(=O)[C@H](CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

Technology Process of Z-Phe-ome

There total 46 articles about Z-Phe-ome which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-Cbz-L-Phe (1161-13-3) → N-carbobenzoxy-L-phenylalanine methyl ester (35909-92-3)

Guidance literature:

With chloro-trimethyl-silane; for 18h;

DOI:10.1021/jo0016834

Reference yield: 100.0%

methanol (67-56-1) + N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester (60379-01-3) → N-carbobenzoxy-L-phenylalanine methyl ester (35909-92-3)

Guidance literature:

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; ethylenediamine; at 20 ℃; for 14h; under 760 Torr;

DOI:10.1016/S0040-4020(00)00771-7

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-Cbz-L-Phe (1161-13-3) → N-carbobenzoxy-L-phenylalanine methyl ester (35909-92-3)

Guidance literature:

In diethyl ether;

DOI:10.1039/b004183l

upstream raw materials:

methanol

N-Cbz-L-Phe

diazomethane

diazomethyl-trimethyl-silane

Downstream raw materials:

Cbz-L-Phe-L-Leu-NH₂

2(S)-(benzyloxycarbonylamino)-6,6,7,7,8,8,9,9,10,10,11,11,11-tridecafluoro-1-phenyl-undecan-3-one

2(S)-(benzyloxycarbonylamino)-3,3-bis(1'H,1'H,2'H,2'H-perfluorooctyl)-1-phenyl-propan-3-ol

N-((benzyloxy)carbonyl)-L-phenylalaninol