(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one
CAS No.:1357580-78-9
Molecular Formula:C₃₁H₃₃ClN₄O₃S
Molecular Weight:577.147
Hs Code.:

(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Synonyms:(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

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Chemical Property of (E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

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Technology Process of (E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

There total 11 articles about (E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1357580-77-8
(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

: 1357580-78-9
(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: C₁₆H₁₇ClN₂*(x)ClH

: 1357580-78-9
(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Cooling with ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1357580-74-5
(E)-tert-butyl 3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)acrylate

: 1357580-78-9
(E)-1-(5-amino-1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 0 - 20 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Cooling with ice

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; camphor-10-sulfonic acid; sodium benzenesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.007