(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one
CAS No.:1357580-77-8
Molecular Formula:C₃₄H₃₇ClN₄O₃S
Molecular Weight:617.212
Hs Code.:

(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Synonyms:(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

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Chemical Property of (E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

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Technology Process of (E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

There total 9 articles about (E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₇ClN₂*(x)ClH

: C₁₈H₂₁ClN₂O₃S*(x)ClH

: 1357580-77-8
(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Cooling with ice;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-03-6
2-(bromomethyl)-1-methyl-5-(methylsulfonyl)pyrrole

: 1357580-77-8
(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

2: 0 - 20 °C

3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Cooling with ice

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: (E)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)acrylic acid trifluoroacetate

: 1357580-77-8
(E)-1-(1-(chloromethyl)-5-(allylamino)-1H-benzo[e]indol-3(2H)-yl)-3-(4-((methyl((1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methyl)amino)methyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Cooling with ice

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.12.007