tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate
CAS No.:1421275-50-4
Molecular Formula:C₂₀H₂₇BrIN₃O₅
Molecular Weight:596.26
Hs Code.:

Synonyms:tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421275-40-2
4-(N'-ethoxycarbonyl-hydrazino)-piperidine-1-carboxylic acid tert-butyl ester

: 1261552-99-1
2-bromo-6-iodobenzoyl chloride

: 1421275-50-4
tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 18h;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1421275-50-4
tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; [bis(acetoxy)iodo]benzene; palladium diacetate / N,N-dimethyl acetamide / 100 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 18 h / 20 °C

With oxalyl dichloride; [bis(acetoxy)iodo]benzene; iodine; palladium diacetate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1421275-50-4
tert-butyl 4-[1-(2-bromo-6-iodobenzoyl)-2-(ethoxycarbonyl)hydrazinyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium cyanoborohydride / methanol / 9 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / 18 h / 20 °C

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol;