(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate
CAS No.:1417603-45-2
Molecular Formula:C₂₈H₃₂N₂O₅
Molecular Weight:476.572
Hs Code.:

Synonyms:(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

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Chemical Property of (S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

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Technology Process of (S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

There total 3 articles about (S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 58-27-5,34524-96-4
menadione

: 112670-47-0
(S)-4-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)butanoic acid

: 1417603-45-2
(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: With ammonium peroxydisulfate; silver nitrate; In water; acetonitrile; at 100 ℃; for 1h;
DOI:10.1002/ejoc.201200722

Reference yield:

: (S)-methyl 4-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)butanoate

: 1417603-45-2
(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 20 h / 20 °C

2: ammonium peroxydisulfate; silver nitrate / water; acetonitrile / 1 h / 100 °C

With ammonium peroxydisulfate; silver nitrate; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.1002/ejoc.201200722

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1417603-45-2
(S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0 - 20 °C

2: sodium hydroxide / methanol / 20 h / 20 °C

3: ammonium peroxydisulfate; silver nitrate / water; acetonitrile / 1 h / 100 °C

With ammonium peroxydisulfate; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ejoc.201200722