((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester

Base Information

• Chemical Name: ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester
• CAS No.: 871331-07-6
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 871331-07-6.mol

Synonyms:((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester

Chemical Property of ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester

There total 4 articles about ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

((R)-7-Oxo-3-phenyl-2,3,4,7-tetrahydro-[1,4]oxazepin-5-yl)-acetic acid methyl ester (871331-02-1) → ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester (871331-07-6)

Guidance literature:

((R)-7-Oxo-3-phenyl-2,3,4,7-tetrahydro-[1,4]oxazepin-5-yl)-acetic acid methyl ester; With acetic acid; In dichloromethane; at 0 ℃;

With sodium cyanoborohydride; In dichloromethane; at 0 - 20 ℃; for 1h;

With ammonium chloride; In water;

DOI:10.1016/j.tetlet.2005.09.114

Reference yield:

(Z)-3-((R)-2-Hydroxy-1-phenyl-ethylamino)-pent-2-enedioic acid dimethyl ester (871331-01-0) → ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester (871331-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 83 percent / NH₄Cl / H₂O

2.1: AcOH / CH₂Cl₂ / 0 °C

2.2: NaBH₃CN / CH₂Cl₂ / 1 h / 0 - 20 °C

2.3: 53 percent / NH₄Cl / H₂O

With sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2005.09.114

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → ((3R,5S)-7-Oxo-3-phenyl-[1,4]oxazepan-5-yl)-acetic acid methyl ester (871331-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / toluene / 48 h / Heating

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 83 percent / NH₄Cl / H₂O

3.1: AcOH / CH₂Cl₂ / 0 °C

3.2: NaBH₃CN / CH₂Cl₂ / 1 h / 0 - 20 °C

3.3: 53 percent / NH₄Cl / H₂O

With sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2005.09.114

upstream raw materials:

((R)-7-Oxo-3-phenyl-2,3,4,7-tetrahydro-[1,4]oxazepin-5-yl)-acetic acid methyl ester

(Z)-3-((R)-2-Hydroxy-1-phenyl-ethylamino)-pent-2-enedioic acid dimethyl ester

3-oxopentanedioic acid dimethyl ester

D-2-phenylglycinol