(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

Base Information

Chemical Name:(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole
CAS No.:920035-09-2
Molecular Formula:C₂₅H₂₅NO₃S
Molecular Weight:419.544
Hs Code.:

Synonyms:(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

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Chemical Property of (2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

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Technology Process of (2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

There total 3 articles about (2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 905859-13-4
(2S)-2-benzyloxymethyl-1-(4-methylphenylsulfonyl)pyrrolidin-4-one

: phenylmagnesium bromide

: 920035-09-2
(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: (2S)-2-benzyloxymethyl-1-(4-methylphenylsulfonyl)pyrrolidin-4-one; phenylmagnesium bromide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h;
DOI:10.1016/j.tet.2006.10.002

Reference yield:

: 100-39-0
benzyl bromide

: 920035-09-2
(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 20 h / Heating

1.2: 82 percent / Jones reagent / acetone / 0.33 h / 0 °C

2.1: tetrahydrofuran / 2 h / -78 - 20 °C

2.2: 73 percent / BF₃*OEt₂ / tetrahydrofuran / 0.25 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tet.2006.10.002

Reference yield:

: 261157-02-2
(2S,4R)-1-(4-methylphenyl)sulfonyl-2-hydroxymethyl-4-(t-butyldimethylsilanyloxy)pyrrolidine

: 920035-09-2
(2S)-2-benzyloxymethyl-4-phenyl-1-(4-methylphenylsulfonyl)-2,5-dihydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 20 h / Heating

1.2: 82 percent / Jones reagent / acetone / 0.33 h / 0 °C

2.1: tetrahydrofuran / 2 h / -78 - 20 °C

2.2: 73 percent / BF₃*OEt₂ / tetrahydrofuran / 0.25 h / 0 - 20 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/j.tet.2006.10.002