Technology Process of methyl 2-(4-(4,4-difluoro-4-phenylbutyl)phenyl)acetate
There total 6 articles about methyl 2-(4-(4,4-difluoro-4-phenylbutyl)phenyl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 20 - 50 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Dess-Martin periodane / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
2: diethylamino-sulfur trifluoride / dichloromethane / 20 - 50 °C / Inert atmosphere
With
diethylamino-sulfur trifluoride; Dess-Martin periodane;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate
2: potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / water; ethyl acetate / 0 °C
3: tetrahydrofuran / 3 h / -60 - 0 °C / Inert atmosphere
4: Dess-Martin periodane / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
5: diethylamino-sulfur trifluoride / dichloromethane / 20 - 50 °C / Inert atmosphere
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; potassium bromide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
