(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

Base Information

Chemical Name:(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate
CAS No.:879572-76-6
Molecular Formula:C₄₁H₅₇NO₄Si
Molecular Weight:655.993
Hs Code.:

Synonyms:(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

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Chemical Property of (2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

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Technology Process of (2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

There total 9 articles about (2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 879572-75-5
(2S,5R,10S)-tert-butyl 5-(benzyloxymethyl)-10-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-azaspiro[4,5]dec-6-ene-1-carboxylate

: 879572-76-6
(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;
DOI:10.1021/ol053010j

Reference yield: 66.0%

: C₄₈H₆₃N₃O₆SSi

: 879572-76-6
(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

Guidance literature:: With sodium cyanoborohydride; zinc(II) chloride; In methanol; for 23h; Inert atmosphere; Reflux;
DOI:10.1002/chem.201701475

Reference yield:

: 879572-72-2
(2S,5S)-tert-butyl 5-(benzyloxymethyl)-2-[(S)-1-(tert-butyldiphenylsilyloxy)oct-7-en-4-yl]-2-vinylpyrrolidine-1-carboxylate

: 879572-76-6
(2S,5S,6S)-tert-butyl 2-(benzyloxymethyl)-6-[3'-(tert-butyldiphenylsilanyloxy)propyl]-1-aza-spiro[4,5]decane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / second generation Grubbs' catalyst / CH₂Cl₂ / 1 h / 40 °C

2: 95 percent / hydrogen; triethylamine / Pd/C / methanol / 12 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ol053010j