tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate

Base Information

• Chemical Name: tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate
• CAS No.: 1042693-72-0
• Molecular Formula: C₁₄H₁₇F₃N₂O₃
• Molecular Weight: 318.296
• Mol file: 1042693-72-0.mol

Synonyms:tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate

Chemical Property of tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate

There total 1 articles about tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + 3-trifluoromethylaniline (98-16-8) → tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate (1042693-72-0)

Guidance literature:

BOC-glycine; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at -20 ℃; for 0.5h; Inert atmosphere;

3-trifluoromethylaniline; With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm800639h

Reference yield: 84.0%

tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate (1042693-72-0) → 2-amino-N-[3-(trifluoromethyl)phenyl]acetamide hydrochloride (936447-60-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

Reference yield: 67.0%

tert-butyl (2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)carbamate (1042693-72-0) + (1S,2S)-2-(1H-benzo[d]imidazol-2-yl)cyclopropane-1-carboxylic acid → (1S,2S)-2-(1H-benzo[d]imidazol-2-yl)-N-(2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)cyclopropane-1-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

upstream raw materials:

BOC-glycine

3-trifluoromethylaniline

Downstream raw materials:

2-amino-N-(3-(trifluoromethyl)phenyl)acetamide

2-amino-N-[3-(trifluoromethyl)phenyl]acetamide hydrochloride

tert-butyl 3-methyl-2-oxo-4-{[(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)amino]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-ene-8-carboxylate

3-methyl-2-oxo-N-(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxamide, hydrochloride salt