Nocardicin G

Base Information

Chemical Name:Nocardicin G
CAS No.:65309-11-7
Molecular Formula:C19H19N3O6
Molecular Weight:385.376
Hs Code.:
Wikidata:Q27154982

Synonyms:Nocardicin G;65309-11-7;FR 29644;(-)-nocardicin G;CHEBI:81024;AKOS030531218;C17355;Q27154982;(2R)-[(3S)-3-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoazetidin-1-yl](4-hydroxyphenyl)acetic acid

Suppliers and Price of Nocardicin G

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NocardicinG
50mg
$ 15950.00

Medical Isotopes, Inc.
NocardicinG
50 mg
$ 15500.00

Total 6 raw suppliers

Chemical Property of Nocardicin G

Chemical Property:

Vapor Pressure:1.23E-27mmHg at 25°C
Boiling Point:808.8°C at 760 mmHg
Flash Point:443°C
PSA：156.68000
Density:1.55g/cm³
LogP:1.72900
XLogP3:-2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:385.12738533
Heavy Atom Count:28
Complexity:599

Purity/Quality:

99% ^*data from raw suppliers

NocardicinG ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(=O)N1C(C2=CC=C(C=C2)O)C(=O)O)NC(=O)C(C3=CC=C(C=C3)O)N
Isomeric SMILES:C1[C@@H](C(=O)N1[C@H](C2=CC=C(C=C2)O)C(=O)O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N
Uses Nocardicin G is a β-lactam antibiotic.

Technology Process of Nocardicin G

There total 13 articles about Nocardicin G which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110207-48-2
(R)-{(S)-3-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-oxo-azetidin-1-yl}-(4-hydroxy-phenyl)-acetic acid tert-butyl ester

: 65309-11-7
(-)-nocardicin G

Guidance literature:: With methoxybenzene; trifluoroacetic acid; 1.) 0 deg C, 15 min, 2.) RT, 30 min;
DOI:10.1021/ja00158a040

Reference yield:

: 110207-46-0
(-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester

: 65309-11-7
(-)-nocardicin G

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂,HCl / 10percent Pd/C / 48 h / 2585.7 Torr

2: 59 percent / i-BuOCOCl/2,6-lutidine / acetone; dimethylformamide / 1.5 h / -5 - 20 °C

3: 90 percent / TFA / various solvent(s) / 1 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)83888-5

Reference yield:

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

: 65309-11-7
(-)-nocardicin G

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent

2: 94 percent / H₂,HCl / 10percent Pd/C / 48 h / 2585.7 Torr

3: 59 percent / i-BuOCOCl/2,6-lutidine / acetone; dimethylformamide / 1.5 h / -5 - 20 °C

4: 90 percent / TFA / various solvent(s) / 1 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)83888-5