Technology Process of epi-nocardicin G-SNAC
There total 17 articles about epi-nocardicin G-SNAC which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid;
In
acetonitrile;
at 20 ℃;
for 0.25h;
DOI:10.1021/jo4007893
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid; water / acetonitrile / 0.25 h / 20 °C
2: trifluoroacetic acid; potassium phosphate / water
With
potassium phosphate; water; trifluoroacetic acid;
In
water; acetonitrile;
DOI:10.1021/jo4007893
- Guidance literature:
-
Multi-step reaction with 8 steps
1: diethylazodicarboxylate; triethyl phosphite / tetrahydrofuran / 12 h / 20 °C / Darkness
2: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 48 h / 2585.81 Torr
3: hydrogenchloride / diethyl ether; water
4: 2,6-dimethylpyridine / N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C
5: trifluoroacetic acid / 0.5 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 12 h / 20 °C
7: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C
8: trifluoroacetic acid; water / acetonitrile / 0.25 h / 20 °C
With
2,6-dimethylpyridine; hydrogenchloride; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; 10 wt% Pd(OH)2 on carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diethylazodicarboxylate; triethyl phosphite;
In
tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo4007893
