5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

Base Information

Chemical Name:5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile
CAS No.:1614245-84-9
Molecular Formula:C₂₄H₂₀FN₅O₂S
Molecular Weight:461.52
Hs Code.:

Synonyms:5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

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Chemical Property of 5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

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Technology Process of 5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

There total 10 articles about 5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1614246-38-6
2-bromo-5-(isopropylsulfonyl)benzonitrile

: 7-cyclopropyl-4-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-7H-imidazo[4,5-c]pyridazine

: 1614245-84-9
5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; at 110 ℃; for 1.5h;

Reference yield:

: 1152496-37-1
2-bromo-5-(isopropylsulfonyl)benzoic acid

: 1614245-84-9
5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water / 1.5 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1614246-37-5
2-bromo-5-(isopropylsulfonyl)benzamide

: 1614245-84-9
5'-(7-cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2'-fluoro-4-(isopropylsulfonyl)-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water / 1.5 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; water;