Technology Process of 2-bromo-5-(isopropylsulfonyl)benzonitrile
There total 5 articles about 2-bromo-5-(isopropylsulfonyl)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h
2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C
With
triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chlorosulfonic acid / 16.66 h / Reflux
2: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C
3: sodium acetate / ethanol / 16 h / Reflux
4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h
5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 20 °C
With
chlorosulfonic acid; sodium acetate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
